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Degrade to survive: the intricate world of piroplasmid proteases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00574491" target="_blank" >RIV/60077344:_____/23:00574491 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/23:43907335

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1471492223001186?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1471492223001186?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.pt.2023.04.010" target="_blank" >10.1016/j.pt.2023.04.010</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Degrade to survive: the intricate world of piroplasmid proteases

  • Original language description

    Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Trends in Parasitology

  • ISSN

    1471-4922

  • e-ISSN

    1471-5007

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    15

  • Pages from-to

    532-546

  • UT code for WoS article

    001027544600001

  • EID of the result in the Scopus database

    2-s2.0-85160750621