Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00575491" target="_blank" >RIV/60077344:_____/23:00575491 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/23:00575491 RIV/60076658:12310/23:43907858 RIV/00216224:14310/23:00133966

Result on the web

<a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010924" target="_blank" >https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010924</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pgen.1010924" target="_blank" >10.1371/journal.pgen.1010924</a>

Result language

angličtina

Original language name

Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock

Original language description

TAIMAN (TAI), the only insect ortholog of mammalian Steroid Receptor Coactivators (SRCs), is a critical modulator of ecdysone and juvenile hormone (JH) signaling pathways, which govern insect development and reproduction. The modulatory effect is mediated by JH-dependent TAI’s heterodimerization with JH receptor Methoprene-tolerant and association with the Ecdysone Receptor complex. Insect hormones regulate insect physiology and development in concert with abiotic cues, such as photo- and thermoperiod. Here we tested the effects of JH and ecdysone signaling on the circadian clock by a combination of microsurgical operations, application of hormones and hormone mimics, and gene knockdowns in the linden bug Pyrrhocoris apterus males. Silencing taiman by each of three non-overlapping double-strand RNA fragments dramatically slowed the free-running period (FRP) to 27–29 hours, contrasting to 24 hours in controls. To further corroborate TAIMAN’s clock modulatory function in the insect circadian clock, we performed taiman knockdown in the cockroach Blattella germanica. Although Blattella and Pyrrhocoris lineages separated ~380 mya, B. germanica taiman silencing slowed the FRP by more than 2 hours, suggesting a conserved TAI clock function in (at least) some insect groups. Interestingly, the pace of the linden bug circadian clock was neither changed by blocking JH and ecdysone synthesis, by application of the hormones or their mimics nor by the knockdown of corresponding hormone receptors. Our results promote TAI as a new circadian clock modulator, a role described for the first time in insects. We speculate that TAI participation in the clock is congruent with the mammalian SRC-2 role in orchestrating metabolism and circadian rhythms, and that TAI/SRCs might be conserved components of the circadian clock in animals.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS Genetics

ISSN

1553-7404

e-ISSN

1553-7404

Volume of the periodical

19

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

25

Pages from-to

e1010924

UT code for WoS article

001159590000001

EID of the result in the Scopus database

2-s2.0-85171900197