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Efficacy of the Vaccine Candidate Based on the P0 Peptide against <i>Dermacentor nitens</i> and <i>Ixodes ricinus</i> Ticks

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00580597" target="_blank" >RIV/60077344:_____/23:00580597 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.mdpi.com/2076-0817/12/11/1365" target="_blank" >https://www.mdpi.com/2076-0817/12/11/1365</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/pathogens12111365" target="_blank" >10.3390/pathogens12111365</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Efficacy of the Vaccine Candidate Based on the P0 Peptide against <i>Dermacentor nitens</i> and <i>Ixodes ricinus</i> Ticks

  • Original language description

    The control of ticks through vaccination offers a sustainable alternative to the use of chemicals that cause contamination and the selection of resistant tick strains. However, only a limited number of anti-tick vaccines have reached commercial realization. In this sense, an antigen effective against different tick species is a desirable target for developing such vaccines. A peptide derived from the tick P0 protein (pP0) conjugated to a carrier protein has been demonstrated to be effective against the Rhipicephalus microplus, Rhipicephalus sanguineus, and Amblyomma mixtum tick species. The aim of this work was to assess the efficacy of this peptide when conjugated to the Bm86 protein against Dermacentor nitens and Ixodes ricinus ticks. An RNAi experiment using P0 dsRNA from I. ricinus showed a dramatic reduction in the feeding of injected female ticks on guinea pigs. In the follow-up vaccination experiments, rabbits were immunized with the pP0-Bm86 conjugate and challenged simultaneously with larvae, nymphs, and the adults of I. ricinus ticks. In the same way, horses were immunized with the pP0-Bm86 conjugate and challenged with D. nitens larva. The pP0-Bm86 conjugate showed efficacies of 63% and 55% against I. ricinus and D. nitens ticks, respectively. These results, combined with previous reports of efficacy for this conjugate, show the promising potential for its development as a broad-spectrum anti-tick vaccine.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    <a href="/en/project/GA20-05736S" target="_blank" >GA20-05736S: The role of Toll pathway in the regulation of tick immune response against tick-transmitted pathogens</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pathogens

  • ISSN

    2076-0817

  • e-ISSN

    2076-0817

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

    1365

  • UT code for WoS article

    001114560700001

  • EID of the result in the Scopus database

    2-s2.0-85178286619