Efficacy of the Vaccine Candidate Based on the P0 Peptide against <i>Dermacentor nitens</i> and <i>Ixodes ricinus</i> Ticks
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00580597" target="_blank" >RIV/60077344:_____/23:00580597 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2076-0817/12/11/1365" target="_blank" >https://www.mdpi.com/2076-0817/12/11/1365</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pathogens12111365" target="_blank" >10.3390/pathogens12111365</a>
Alternative languages
Result language
angličtina
Original language name
Efficacy of the Vaccine Candidate Based on the P0 Peptide against <i>Dermacentor nitens</i> and <i>Ixodes ricinus</i> Ticks
Original language description
The control of ticks through vaccination offers a sustainable alternative to the use of chemicals that cause contamination and the selection of resistant tick strains. However, only a limited number of anti-tick vaccines have reached commercial realization. In this sense, an antigen effective against different tick species is a desirable target for developing such vaccines. A peptide derived from the tick P0 protein (pP0) conjugated to a carrier protein has been demonstrated to be effective against the Rhipicephalus microplus, Rhipicephalus sanguineus, and Amblyomma mixtum tick species. The aim of this work was to assess the efficacy of this peptide when conjugated to the Bm86 protein against Dermacentor nitens and Ixodes ricinus ticks. An RNAi experiment using P0 dsRNA from I. ricinus showed a dramatic reduction in the feeding of injected female ticks on guinea pigs. In the follow-up vaccination experiments, rabbits were immunized with the pP0-Bm86 conjugate and challenged simultaneously with larvae, nymphs, and the adults of I. ricinus ticks. In the same way, horses were immunized with the pP0-Bm86 conjugate and challenged with D. nitens larva. The pP0-Bm86 conjugate showed efficacies of 63% and 55% against I. ricinus and D. nitens ticks, respectively. These results, combined with previous reports of efficacy for this conjugate, show the promising potential for its development as a broad-spectrum anti-tick vaccine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/GA20-05736S" target="_blank" >GA20-05736S: The role of Toll pathway in the regulation of tick immune response against tick-transmitted pathogens</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pathogens
ISSN
2076-0817
e-ISSN
2076-0817
Volume of the periodical
12
Issue of the periodical within the volume
11
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1365
UT code for WoS article
001114560700001
EID of the result in the Scopus database
2-s2.0-85178286619