Holocentromeres can consist of merely a few megabase-sized satellite arrays

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00584244" target="_blank" >RIV/60077344:_____/23:00584244 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41467-023-38922-7" target="_blank" >https://www.nature.com/articles/s41467-023-38922-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-023-38922-7" target="_blank" >10.1038/s41467-023-38922-7</a>

Result language
angličtina
Original language name
Holocentromeres can consist of merely a few megabase-sized satellite arrays
Original language description
The centromere is the chromosome region where microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere, holocentric species usually distribute hundreds of centromere units along the entire chromatid. We assembled the chromosome-scale reference genome and analyzed the holocentromere and (epi)genome organization of the lilioid Chionographis japonica. Remarkably, each of its holocentric chromatids consists of only 7 to 11 evenly spacedmegabase-sized centromere-specific histone H3-positive units. These units contain satellite arrays of 23 and 28 bp-long monomers capable of forming palindromic structures. Like monocentric species, C. japonica forms clustered centromeres in chromocenters at interphase. In addition, the large-scale eu- and heterochromatin arrangement differs between C. japonica and other known holocentric species. Finally, using polymer simulations, we model the formation of prometaphase line-like holocentromeres from interphase centromere clusters. Our findings broaden the knowledge about centromere diversity, showing that holocentricity is not restricted to species with numerous and small centromere units.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
<a href="/en/project/GA20-25440S" target="_blank" >GA20-25440S: Changes in kinetochore composition and structure associated with holocentric chromosome formation</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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