Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00584265" target="_blank" >RIV/60077344:_____/23:00584265 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00128-022-03658-5" target="_blank" >https://link.springer.com/article/10.1007/s00128-022-03658-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00128-022-03658-5" target="_blank" >10.1007/s00128-022-03658-5</a>
Alternative languages
Result language
angličtina
Original language name
Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine
Original language description
The widespread occurrence of cyanobacteria blooms damages the water ecosystem and threatens the safety of potable water and human health. Exogenous L-lysine significantly inhibits the growth of a dominant cyanobacteria Microcystis aeruginosa in freshwater. However, the molecular mechanism of how lysine inhibits the growth of M. aeruginosa is unclear. In this study, both non-target and target metabolomic analysis were performed to investigate the effects of algicide L-lysine. The results showed that 8 mg L- 1 lysine most likely disrupts the metabolism of amino acids, especially the arginine and proline metabolism. According to targeted amino acid metabolomics analysis, only 3 amino acids (L-arginine, ornithine, and citrulline), which belong to the ornithine-ammonia cycle (OAC) in arginine metabolic pathway, showed elevated levels. The intracellular concentrations of ornithine, citrulline, and arginine increased by 115%, 124%, and 19.4%, respectively. These results indicate that L-lysine may affect arginine metabolism and OAC to inhibit the growth of M. aeruginosa.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bulletin of Environmental Contamination and Toxicology
ISSN
0007-4861
e-ISSN
1432-0800
Volume of the periodical
110
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
12
UT code for WoS article
000898798600005
EID of the result in the Scopus database
2-s2.0-85143799207