Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00584803" target="_blank" >RIV/60077344:_____/24:00584803 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.celrep.2024.113740" target="_blank" >https://doi.org/10.1016/j.celrep.2024.113740</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2024.113740" target="_blank" >10.1016/j.celrep.2024.113740</a>
Alternative languages
Result language
angličtina
Original language name
Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
Original language description
The organelle paralogy hypothesis (OPH) aims to explain the evolution of non-endosymbiotically derived organelles. It predicts that lineagespecific pathways or organelles should result when identityencoding membranetrafficking components duplicate and coevolve. Here, we investigate the presence of such lineagespecific membranetrafficking machinery paralogs in Apicomplexa, a globally important parasitic lineage. We are able to identify 18 paralogs of known membranetrafficking machinery, in several cases coincident with the presence of new endomembrane organelles in apicomplexans or their parent lineage, the Alveolata. Moreover, focused analysis of the apicomplexan Arf-like small GTPases (i.e., ArlX3) revealed a specific postGolgi trafficking pathway. This pathway appears involved in delivery of proteins to micronemes and rhoptries, with knockdown demonstrating reduced invasion capacity. Overall, our data have identified an unforeseen post-Golgi trafficking pathway in apicomplexans and are consistent with the OPH mechanism acting to produce endomembrane pathways or organelles at various evolutionary stages across the alveolate lineage.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
2211-1247
Volume of the periodical
43
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
113740
UT code for WoS article
001185223800001
EID of the result in the Scopus database
2-s2.0-85185401939