A guide to the use of bioassays in exploration of natural resources
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00585502" target="_blank" >RIV/60077344:_____/24:00585502 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/24:73624563
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0734975024000016?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0734975024000016?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biotechadv.2024.108307" target="_blank" >10.1016/j.biotechadv.2024.108307</a>
Alternative languages
Result language
angličtina
Original language name
A guide to the use of bioassays in exploration of natural resources
Original language description
Bioassays are the main tool to decipher bioactivities from natural resources thus their selection and quality are critical for optimal bioprospecting. They are used both in the early stages of compounds isolation/purification/ identification, and in later stages to evaluate their safety and efficacy. In this review, we provide a comprehensive overview of the most common bioassays used in the discovery and development of new bioactive compounds with a focus on marine bioresources. We present a comprehensive list of practical considerations for selecting appropriate bioassays and discuss in detail the bioassays typically used to explore antimicrobial, antibiofilm, cytotoxic, antiviral, antioxidant, and anti-ageing potential. The concept of quality control and bioassay validation are introduced, followed by safety considerations, which are critical to advancing bioactive compounds to a higher stage of development. We conclude by providing an application-oriented view focused on the development of pharmaceuticals, food supplements, and cosmetics, the industrial pipelines where currently known marine natural products hold most potential. We highlight the importance of gaining reliable bioassay results, as these serve as a starting point for application-based development and further testing, as well as for consideration by regulatory authorities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biotechnology Advances
ISSN
0734-9750
e-ISSN
1873-1899
Volume of the periodical
71
Issue of the periodical within the volume
March–April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
35
Pages from-to
108307
UT code for WoS article
001170332700001
EID of the result in the Scopus database
2-s2.0-85183459363