The structure of immature tick-borne encephalitis virus supports the collapse model of flavivirus maturation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00587841" target="_blank" >RIV/60077344:_____/24:00587841 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/24:00136505 RIV/00027162:_____/24:N0000067
Result on the web
<a href="https://www.science.org/doi/10.1126/sciadv.adl1888" target="_blank" >https://www.science.org/doi/10.1126/sciadv.adl1888</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.adl1888" target="_blank" >10.1126/sciadv.adl1888</a>
Alternative languages
Result language
angličtina
Original language name
The structure of immature tick-borne encephalitis virus supports the collapse model of flavivirus maturation
Original language description
We present structures of three immature tick-borne encephalitis virus (TBEV) isolates. Our atomic models of the major viral components, the E and prM proteins, indicate that the pr domains of prM have a critical role in holding the heterohexameric prM3E3 spikes in a metastable conformation. Destabilization of the prM furin-sensitive loop at acidic pH facilitates its processing. The prM topology and domain assignment in TBEV is similar to the mosquito-borne Binjari virus, but is in contrast to other immature flavivirus models. These results support that prM cleavage, the collapse of E protein ectodomains onto the virion surface, the large movement of the membrane domains of both E and M, and the release of the pr fragment from the particle render the virus mature and infectious. Our work favors the collapse model of flavivirus maturation warranting further studies of immature flaviviruses to determine the sequence of events and mechanistic details driving flavivirus maturation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
10
Issue of the periodical within the volume
27
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
eadl1888
UT code for WoS article
001262993200012
EID of the result in the Scopus database
2-s2.0-85197686140