Effect of bisphenol S and bisphenol A on morphometric and hormonal changes of thyroid gland and iodine concentration in urine of Wistar rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00603882" target="_blank" >RIV/60077344:_____/24:00603882 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12220/24:43908428

Result on the web

<a href="https://doi.org/10.5513/JCEA01/25.2.4198" target="_blank" >https://doi.org/10.5513/JCEA01/25.2.4198</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5513/JCEA01/25.2.4198" target="_blank" >10.5513/JCEA01/25.2.4198</a>

Result language

angličtina

Original language name

Effect of bisphenol S and bisphenol A on morphometric and hormonal changes of thyroid gland and iodine concentration in urine of Wistar rats

Original language description

Bisphenol S (BPS) is the major substitute of the endocrine disruptor bisphenol A (BPA). Due to the presence of strong double bonds, BPS is more resistant to biodegradation and therefore more BPS remains in the environment. Numerous studies show that BPS disrupts the reproductive, nervous, and cardiovascular systems and could have an impact on thyroid hormones. The study aimed to analyze the effects of a 10week exposition of BPS and BPA on lipid markers, morphometric parameters of the rat thyroid gland, the thyroid stimulating hormone (TSH) levels and the influence of BPS on urine iodine concentration. Male Wistar rats received BPS in sunflower oil daily by gavage. The control group (GI) received only the vehicle. The BPS experimental group two (GII) received 4 ug/kg/day, group three (GIII) received 50 ug/kg/day, and group four (GIV) received 100 mg BPS/kg/day. Group five (GV) received 100 mg BPA/kg/day. Groups four and five were made to compare the influence of high concentration between BPS and BPA. Results show the influence of BPS and BPA on body weight, triacylglycerols, cholesterol and total protein concentration. Morphometric changes in the size of thyroid gland follicles show a bigger influence of BPS than BPA. Results show also increasing in TSH concentrations in all groups with bisphenols up to physiology standards of Wistar rats (GI 3.14 +/- 1.28 ng/ml, GII 5.12 +/- 1.16 ng/ml, GIII 5.55 +/- 2.39 ng/ml, GIV 5.56 +/- 1.98 ng/ml, GV 4.47 +/- 1.09 ng/ml) and influence of BPA and BPS on higher iodine concentrations in urine.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Central European Agriculture

ISSN

1332-9049

e-ISSN

1332-9049

Volume of the periodical

25

Issue of the periodical within the volume

2

Country of publishing house

HR - CROATIA

Number of pages

9

Pages from-to

461-469

UT code for WoS article

001263449800016

EID of the result in the Scopus database

2-s2.0-85197869861