Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00604426" target="_blank" >RIV/60077344:_____/24:00604426 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/24:43908355
Result on the web
<a href="https://www.science.org/doi/10.1126/sciadv.adk7535" target="_blank" >https://www.science.org/doi/10.1126/sciadv.adk7535</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.adk7535" target="_blank" >10.1126/sciadv.adk7535</a>
Alternative languages
Result language
angličtina
Original language name
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes
Original language description
Cyanobacteria use large antenna complexes called phycobilisomes (PBSs) for light harvesting. However, intense light triggers non-photochemical quenching, where the orange carotenoid protein (OCP) binds to PBS, dissipating excess energy as heat. The mechanism of efficiently transferring energy from phycocyanobilins in PBS to canthaxanthin in OCP remains insufficiently understood. Using cryo-electron microscopy, we unveiled the OCP-PBS complex structure at 1.6- to 2.1-angstrom resolution, showcasing its inherent flexibility. Using multiscale quantum chemistry, we disclosed the quenching mechanism. Identifying key protein residues, we clarified how canthaxanthin's transition dipole moment in its lowest-energy dark state becomes large enough for efficient energy transfer from phycocyanobilins. Our energy transfer model offers a detailed understanding of the atomic determinants of light harvesting regulation and antenna architecture in cyanobacteria.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GX19-28323X" target="_blank" >GX19-28323X: Relation between structure and function of carotenoids: New pathways to answer unresolved questions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
10
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
eadk7535
UT code for WoS article
001198102900002
EID of the result in the Scopus database
2-s2.0-85190085264