FOF1-ATP synthase: When it pays to go in reverse
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00604983" target="_blank" >RIV/60077344:_____/24:00604983 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.bbabio.2024.149174" target="_blank" >https://doi.org/10.1016/j.bbabio.2024.149174</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
FOF1-ATP synthase: When it pays to go in reverse
Original language description
FoF1-ATP synthase is a reversible nanomachine that synthesizes or hydrolyzes ATP depending on the bioenergetic properties of the mitochondria. A perfect example of this dual functionality is found in the mammalian pathogen Trypanosoma brucei. During the switch between the mammalian and insect host, the activity of ATP synthase also changes. In the mammalian host bloodstream, abundant glucose allows the parasite to fully utilize its aerobic glycolysis, which is linked to respiration via the alternative oxidase, and in the absence of complexes III and IV of the electron transport chain (ETC), the mitochondrial membrane potential is maintained by the reverse activity of ATP synthase. In contrast, the parasite in the midgut of the insect vector, tsetse fly, consumes abundant amino acids and utilizes a fully developed cytochrome-containing ETC and ATP synthase to generate ATP by oxidative phosphorylation. Expression of the ATP synthase inhibitory peptide IF1 fluctuates as it is absent in the bloodstream form (BF) parasites and abundant in the procyclic form (PF) inhabiting the tsetse midgut. Therefore, the regulation of IF1 gene expression appears to be crucial for the correct developmental progression of the parasite.n
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů