Insights into extracellular vesicle biogenesis and secretion of the tapeworm Hymenolepis diminuta: host interaction and cultivation dynamics q

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00617104" target="_blank" >RIV/60077344:_____/25:00617104 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/25:43909995
Result on the web
<a href="https://doi.org/10.1016/j.ijpara.2024.11.005" target="_blank" >https://doi.org/10.1016/j.ijpara.2024.11.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpara.2024.11.005" target="_blank" >10.1016/j.ijpara.2024.11.005</a>

Result language
angličtina
Original language name
Insights into extracellular vesicle biogenesis and secretion of the tapeworm Hymenolepis diminuta: host interaction and cultivation dynamics q
Original language description
Extracellular vesicles (EVs) from parasites have been identified as potent modulators of host-parasite interactions. However, their biogenesis and secretory activity are still poorly understood. Here we present a comprehensive examination of the secretory dynamics of two distinct EV fractions isolated from the adult tapeworm Hymenolepis diminuta. Additionally, we perform a detailed analysis of changes in proteomic content and morphology during EV secretion, utilising electron tomography to shed light on a previously described novel mechanism of EV biogenesis via bead-like protrusion. Our findings reveal a significant decrease in EV secretion between 24 and 48 h of in vitro cultivation when external host stimuli are no longer present. Finally, this study addresses, for the first known time, the potential bias in EV analysis resulting from extended in vitro cultivation of model parasites. (c) 2024 Published by Elsevier Ltd on behalf of Australian Society for Parasitology.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)