Metabolomic signatures associated with cold adaptation and seasonal acclimation of Drosophila: profiling of 43 species

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00618044" target="_blank" >RIV/60077344:_____/25:00618044 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/25:43909927

Result on the web

<a href="https://journals.biologists.com/jeb/article/228/5/JEB250076/367323/Metabolomic-signatures-associated-with-cold" target="_blank" >https://journals.biologists.com/jeb/article/228/5/JEB250076/367323/Metabolomic-signatures-associated-with-cold</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1242/jeb.250076" target="_blank" >10.1242/jeb.250076</a>

Result language

angličtina

Original language name

Metabolomic signatures associated with cold adaptation and seasonal acclimation of Drosophila: profiling of 43 species

Original language description

Cold tolerance is a key determinant of poleward colonization in insects. However, the physiological basis underlying interspecific differences in cold tolerance is not fully understood. Here, we analyzed cold tolerance and metabolomic profiles in warm- and coldacclimated phenotypes of 43 Drosophila species representing a latitudinal gradient from the tropics to the boreal zone. We found a strong positive correlation between cold tolerance and climatic variables associated with habitat seasonality and temperature. Including the effects of cold acclimation, we found most species have similar ‘safety margins’, measured as the difference between the average environmental temperature and the lower lethal temperature. Searching for metabolomic signatures of cold tolerance, we found that the warm-acclimated flies of cold-hardy species had moderately but significantly higher constitutive signals of putative cryoprotectants such as trehalose, glucose, glycerol and mannitol/sorbitol. Cold acclimation (and the transition to a winter dormant phenotype) resulted in a strong accumulation of myoinositol, which occurred only in species of the virilis group. Other temperate and boreal species either showed only moderate, idiosyncratic accumulations of sugars/polyols and free amino acids, or did not accumulate any ‘classical’ cryoprotectant at all. Thus, our results suggest that the colonization of boreal regions by Drosophila does not necessarily depend on the seasonal accumulation of classical cryoprotectants. In contrast, virtually all cold-acclimated species showed a significant increase in products of phospholipid catabolism, suggesting that remodeling of biological membranes is a clear and ubiquitous signature of cold acclimation in Drosophila.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GA23-06518S" target="_blank" >GA23-06518S: Diversity and physiological roles of small cryoprotective molecules in drosophilid flies: focusing on mitochondrial membranes.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Experimental Biology

ISSN

0022-0949

e-ISSN

1477-9145

Volume of the periodical

228

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

250076

UT code for WoS article

001461192200004

EID of the result in the Scopus database

2-s2.0-105000256507