Diplonemid protists possess exotic endomembrane machinery, impacting models of membrane trafficking in modern and ancient eukaryotes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00619121" target="_blank" >RIV/60077344:_____/25:00619121 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/25:A2603CLY RIV/60076658:12310/25:43909897 RIV/00216208:11310/25:10497809
Result on the web
<a href="https://doi.org/10.1016/j.cub.2025.02.032" target="_blank" >https://doi.org/10.1016/j.cub.2025.02.032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cub.2025.02.032" target="_blank" >10.1016/j.cub.2025.02.032</a>
Alternative languages
Result language
angličtina
Original language name
Diplonemid protists possess exotic endomembrane machinery, impacting models of membrane trafficking in modern and ancient eukaryotes
Original language description
Diplonemids are among the most abundant and species-rich protists in the oceans. Marine heterotrophic flagellates, including diplonemids, have been suggested to play important roles in global biogeochemical cles. Diplonemids are also the sister taxon of kinetoplastids, home to trypanosomatid parasites of global health importance, and thus are informative about the evolution of kinetoplastid biology. However, genomic and cellular complement that underpins diplonemids' highly successful lifestyle is underexplored. At the same time, our framework describing cellular processes may not be as broadly applicable as sumed, as it is largely derived from animal and fungal model organisms, a small subset of extant eukaryotic diversity. In addition to uniquely evolved machinery in animals and fungi, there exist components sporadic (i.e., patchy) distributions across other eukaryotes. A most intriguing subset are components (spacing diaeresis>tnarlogs) stochastically present in a wide range of eukaryotes but lost in animal and/or fungal models. Such components are considered exotic curiosities but may be relevant to inferences about the complexity of the last eukaryotic common ancestor (LECA) and frameworks of modern cell biology. Here, we comparative genomics and phylogenetics to comprehensively assess the membrane-trafficking system diplonemids. They possess several proteins thought of as kinetoplastid specific, as well as an extensive set of patchy proteins, including jo<spacing diaeresis>tnarlogs. Diplonemids apparently function with endomembrane machinery distinct from existing cell biological models but comparable with other free-living heterotrophic protists, highlighting the importance of including such exotic components when considering different models ancient eukaryotic genomic complexity and the cell biology of non-opisthokont organisms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Biology
ISSN
0960-9822
e-ISSN
1879-0445
Volume of the periodical
35
Issue of the periodical within the volume
APR 2025
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
7
UT code for WoS article
001465193300001
EID of the result in the Scopus database
2-s2.0-86000745219