You can go your own way: The targeting signals of trypanosomatid parasites
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00638026" target="_blank" >RIV/60077344:_____/25:00638026 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/25:43909851
Result on the web
<a href="https://doi.org/10.1371/journal.ppat.1013326" target="_blank" >https://doi.org/10.1371/journal.ppat.1013326</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.ppat.1013326" target="_blank" >10.1371/journal.ppat.1013326</a>
Alternative languages
Result language
angličtina
Original language name
You can go your own way: The targeting signals of trypanosomatid parasites
Original language description
Targeting and directing cytosol-synthesized proteins into organelles and cellular compartments constitutes a universal eukaryotic challenge. The discovery that specific peptide sequences are responsible for this localization not only earned a Nobel prize, but also provided a powerful tool for investigating eukaryotic evolution and diversification [1]. While the term ‘targeting signal’ encompasses a broad range of sequences with varying properties, here we define them as sequences—or a set of sequences—that are both necessary and sufficient to ensure a protein reaches its correct cellular localization. Parasitic trypanosomatids, represented primarily by model protist Trypanosoma brucei, constitute the most thoroughly investigated eukaryotes in this regard outside of opisthokonts and plants. Here we provide a protistan perspective on the targeting signals, both innovated and derived, employed by trypanosomatid flagellates for this purpose (Fig 1).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GX23-06479X" target="_blank" >GX23-06479X: What do the most abundant oceanic protistan proteins actually do?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Pathogens
ISSN
1553-7366
e-ISSN
1553-7374
Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
e1013326
UT code for WoS article
001542579800006
EID of the result in the Scopus database
2-s2.0-105012179314