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Comprehensive tools for culturing Blastocystis: A standardized resource for research and diagnostics

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00638364" target="_blank" >RIV/60077344:_____/25:00638364 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1002/cpz1.70175" target="_blank" >https://doi.org/10.1002/cpz1.70175</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/cpz1.70175" target="_blank" >10.1002/cpz1.70175</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comprehensive tools for culturing Blastocystis: A standardized resource for research and diagnostics

  • Original language description

    Blastocystis spp. is a widely prevalent anaerobic protozoan of uncertain pathogenicity found in the gastrointestinal tracts of over 1 billion people worldwide. Despite its potential significance in health and disease, Blastocystis spp. remains challenging to culture axenically due to its anaerobic nature and the diversity of its genetic subtypes. This manuscript presents a standardized toolkit for culturing Blastocystis spp. in xenic and axenic conditions, detailing protocols for the preparation of appropriate liquid and solid media, cryopreservation, and inoculation. By providing a comprehensive set of tools and methodologies, this work aims to streamline research on Blastocystis spp., enabling reproducibility, subtype characterization, and advancements in understanding its role in the gut microbiome and host health. (c) 2025 The Author(s). Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Establishment of xenic Blastocystis culture from stool samples in liquid mediumBasic Protocol 2: Subculturing from existing Blastocystis liquid cultureSupport Protocol 1: Preparation of modified Jones' medium for Blastocystis culturingSupport Protocol 2: Preparation of trypticase-yeast extract-serum-gastric mucin-9 (TSGYM-9) medium for Blastocystis culturingSupport Protocol 3: Preparation of liver extract-yeast extract-serum-gastric mucin (LYSGM) medium for Blastocystis culturingBasic Protocol 3: Subculturing xenic Blastocystis cultures in diphasic mediumSupport Protocol 4: Preparation of Robinson's medium for Blastocystis culturingSupport Protocol 5: Preparation of Ringer's agar slants for Blastocystis culturingBasic Protocol 4: Axenization of Blastocystis culturesBasic Protocol 5: Subculturing axenic Blastocystis cultures in diphasic mediumSupport Protocol 6: Preparation of Boeck and Drbohlav's Locke-egg serum (LES) medium for Blastocystis culturingSupport Protocol 7: Preparation of Boeck and Drbohlav's diphasic modified medium (BDMM) for Blastocystis culturingBasic Protocol 6: Establishment of axenic Blastocystis cultures in Iscove's modified Dulbecco's medium (IMDM)Basic Protocol 7: Establishment of axenic Blastocystis cultures in soft IMDM agarBasic Protocol 8: Establishment of axenic Blastocystis cultures on solid IMDM agarBasic Protocol 9: Optimized method for establishing axenic Blastocystis cultures on solid IMDM agarBasic Protocol 10: Establishment of axenic Blastocystis cultures in semi-solid Locke's agarBasic Protocol 11: Cryopreservation of xenic Blastocystis culturesBasic Protocol 12: Cryopreservation of axenic Blastocystis culturesBasic Protocol 13: Inoculation of liquid medium with xenic Blastocystis cultures from frozen stocksBasic Protocol 14: Inoculation of liquid medium with axenic Blastocystis cultures from frozen stocks

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2025

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Protocols

  • ISSN

    2691-1299

  • e-ISSN

    2691-1299

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    36

  • Pages from-to

    e70175

  • UT code for WoS article

    001550500900001

  • EID of the result in the Scopus database

    2-s2.0-105013536601