Lyme disease control 2.0: Advances and opportunities coming with Lyme disease vaccine VLA15

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00644009" target="_blank" >RIV/60077344:_____/25:00644009 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1371/journal.ppat.1013747" target="_blank" >https://doi.org/10.1371/journal.ppat.1013747</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.ppat.1013747" target="_blank" >10.1371/journal.ppat.1013747</a>

Result language
angličtina
Original language name
Lyme disease control 2.0: Advances and opportunities coming with Lyme disease vaccine VLA15
Original language description
Lyme disease (LD) remains the most prevalent vector-borne disease in the Northern Hemisphere, with over 100,000 cases reported annually in Europe, and ~476,000 in the United States. Although LD can be treated with antibiotics, if detected early, there is currently no licensed vaccine available for humans to prevent infection. One of the key challenges in developing an effective vaccine against LD stems from the complex biology of Borrelia outer surface proteins (Osps), whose expression is dynamically regulated in response to distinct environmental cues, in both the arthropod vector and vertebrate host (Fig 1). Among the predominant outer surface proteins, OspC expression is induced in ticks during Borrelia transmission, and is sustained during early mammalian host infection, while the expression of OspA is restricted only to the tick phase and is no longer expressed in Borrelia once the infection is established in the mammalian host. As a result, infected humans only rarely develop anti-OspA antibodies. Yet, OspA has proven to be a highly effective vaccine antigen, as it induces antibodies that bind to Borrelia within attached ticks, preventing their transmission.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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