Antimicrobiota vaccine induces lysine-mediated modulation of tick immunity affecting Borrelia colonization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00644674" target="_blank" >RIV/60077344:_____/25:00644674 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/25:00644206 RIV/60076658:12310/25:43911211
Result on the web
<a href="https://doi.org/10.1093/femsec/fiaf082" target="_blank" >https://doi.org/10.1093/femsec/fiaf082</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/femsec/fiaf082" target="_blank" >10.1093/femsec/fiaf082</a>
Alternative languages
Result language
angličtina
Original language name
Antimicrobiota vaccine induces lysine-mediated modulation of tick immunity affecting Borrelia colonization
Original language description
Tick microbiota influences Borrelia colonization, but changes in the microbiota-derived metabolite and how this affects tick physiology and vector competence is unclear. We investigated whether microbiota-induced metabolite modifications influence tick physiology and pathogen transmission. Using an antimicrobiota vaccine (live Escherichia coli) to immunize mice, we generated host antibodies that modulated the tick microbiome, decreasing bacterial abundance and increasing lysine levels in ticks. Elevated lysine correlated with increased tick weight. Lysine supplementation experiments enhanced defensin expression with DefMT6 exhibiting anti-Borrelia activity, reducing pathogen load in ticks. Our findings demonstrate that antimicrobiota vaccines induce metabolite changes, affecting tick physiology, immunity, and vector competence. These insights open new avenues for developing microbiota-targeted strategies to control tick-borne diseases
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEMS Microbiology Ecology
ISSN
0168-6496
e-ISSN
1574-6941
Volume of the periodical
101
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
fiaf082
UT code for WoS article
001555274900001
EID of the result in the Scopus database
2-s2.0-105013835291