Epigenome and interactome profiling uncovers principles of distal regulation in the barley genome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F26%3A00646273" target="_blank" >RIV/60077344:_____/26:00646273 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/26:00646273
Result on the web
<a href="https://doi.org/10.1016/j.xgen.2025.101037" target="_blank" >https://doi.org/10.1016/j.xgen.2025.101037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.xgen.2025.101037" target="_blank" >10.1016/j.xgen.2025.101037</a>

Result language
angličtina
Original language name
Epigenome and interactome profiling uncovers principles of distal regulation in the barley genome
Original language description
Regulation of transcription initiation is the ground level of modulating gene expression during plant development. This process relies on interactions between transcription factors and cis-regulatory elements (CREs), which become promising targets for crop bioengineering. To annotate CREs in the barley genome and understand mechanisms of distal regulation, we profiled several epigenetic features across three stages of barley embryo and leaves and performed HiChIP to identify activating and repressive genomic interactions. Using machine learning, we integrated the data into seven chromatin states, predicting similar to 77,000 CRE candidates, collectively representing 1.43% of the barley genome. Identified genomic interactions, often spanning multiple genes, linked thousands of predicted CREs with their putative targets and revealed notably frequent promoter-promoter contacts. Using the LEA gene family as an example, we discuss possible roles of these interactions in transcription regulation. On the Vrn3 gene, we demonstrate the potential of our datasets to predict CREs for other developmental stages.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2026
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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