SmD1 is required for spliced leader biogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077409%3A_____%2F04%3A00104485" target="_blank" >RIV/60077409:_____/04:00104485 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

SmD1 is required for spliced leader biogenesis

Original language description

The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected

Czech name

Protein SmD1 je nezbytný pro biogenezi spliced leader RNA

Czech description

Na sekvenci spliced leader RNA se nachází vazebné místo pro Sm proteiny, které je důležité pro správné zrání spliced leader RNA a její účast v tran-splicing procesu. Vypnutí SmD1 genu u Trypanosoma brucei pomocí RNA interference způsobilo změny ve zráníspliced leader RNA. Dochází ke špatné formaci 3´konce, pouze k částečné formaci čepičky 4 a k akumulaci spliced leader RNA v cytoplasmě. U28 pseudouridilace byla nepostižena

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Eukaryotic Cell

ISSN

1535-9778

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

241-244

UT code for WoS article

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EID of the result in the Scopus database

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