The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F00%3A00000340" target="_blank" >RIV/60162694:G16__/00:00000340 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G38__/00:00000340

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats

Original language description

The influence of some anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the efficacy of antidotal treatment to eliminate soman induced disturbance of respiration and circulation was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. Our findings confirm that anticholinergic drugs with the strong central antimuscarinic activity, such as benactyzine, biperiden and especially scopolamine, seem to be more effective adjuncts to HI-6 treatmentof severe acute soman-induced poisoning than atropine.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

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Volume of the periodical

154

Issue of the periodical within the volume

1-3

Country of publishing house

IE - IRELAND

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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