Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F00%3A00000359" target="_blank" >RIV/60162694:G16__/00:00000359 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/00:00001323 RIV/60162694:G38__/00:00000359

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

Original language description

In eukaryotic cells the activity of cyclin dependent kinases (CDKs) is precisely regulated. This regulation maintains a proper coordination of the individual steps in cell division cycle. Due to the fact that the family of natural CDK inhibitors (CDKIs)belong to the most frequently mutated proteins in cancer cells, molecules that could mimic their biological activities are attractive candidates for anti-cancer treatment. The aim of this study was use 2-DE coupled with multivariate principal component analysis (PCA) to characterize the quantitative changes in the protein composition of the CEM T-lymphoblastic leukemia cell line after treatment with bohemine (BOH), a synthetic olomoucin derived CDKI. Cell classification, reflecting protein patterns,clearly distinguished two main groups: one group consists of 9, 12 and 24 - hour treated BOH cells while the second is represented by the 0 and 24 - hour control untreated cells and the 6- hour BOH exposed CEM lymphoblasts. Discriminant prote

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

17

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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