The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F00%3A00000366" target="_blank" >RIV/60162694:G16__/00:00000366 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G38__/00:00000366

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro

Original language description

A number of studies documented that the heavy metals are not only toxic for the organisms but they may modulate immune responses. The immunomodulatory activity was proved in several in vivo and in vitro model systems. In the current study, immunomodulatory activities of lead and cadmium are presented. The viability of both lymphocytes and macrophages was affected by heavy metals in a dose- and time-dependent manner. In the case of lead, the depression of N-oxide production closely correlated with increased blast transformation of spleen cells induced by concanavalin A (ConA). On the contrary, cadmium suppressed the production of N-oxides but stimulated significantly the proliferation of spleen cells. The production of cytokines by lymphocytes and macrophages was dependent on the in vitro model used. Generally, the treatment of macrophages with lead results in disregulation of the production of proinflammatory cytokines [tumour necrosis factor alpha (TNF-alpha), interleukin 1alpha (IL-1

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/LN00A033" target="_blank" >LN00A033: The proteome center for the study of intracellular parasitism of microbes</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology in Vitro

ISSN

0887-2333

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

february

Country of publishing house

XX - stateless person

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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