The long term effects of low-level sarin inhalation exposure on cognitive functions in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F01%3A00000517" target="_blank" >RIV/60162694:G16__/01:00000517 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The long term effects of low-level sarin inhalation exposure on cognitive functions in rats
Original language description
To study the influence of low level sarin exposure on cognitive functions, male albino Wistar rats were exposed to low concentrations of sarin for 60 minutes in the inhalation chamber. Three concentrations of sarin were chosen: clinically and laboratoryasymptomatic concentration (0.8 mg/L) - LEVEL 1 clinically aymptomatic concentration with significant inhibition of erythrocyte acetylcholinesterase (1.25 mg/L) - LEVEL 2 non-convulsive symptomatic concentration (2.5 mg/L) - LEVEL 3 In addition,one groupof rats was exposed to clinically asymptomatic concentration (1.25 mg/L) of sarin repeatedly (three times during one week). Testing of cognitive functions was carried out using the Y-maze evaluating learning and spatial memory. The avoidanc e behaviourof sarin-exposed rats in the Y-maze was tested several times within seven weeks following sarin inhalation exposure to look for any cognitive impairments. The results were compared to the Y-maze performance of control rats exposed to pure
Czech name
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Czech description
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Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Proceedings of Seventh International Symposium on protection against chemical and biological warfare agents
ISBN
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Number of pages of the result
1
Pages from-to
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Number of pages of the book
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Publisher name
Commitee of Symposium
Place of publication
Stockholm
UT code for WoS chapter
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