Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F03%3A00000900" target="_blank" >RIV/60162694:G16__/03:00000900 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G38__/03:00000900

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats

Original language description

To study the influence of pharmacological pretreatment (PANPAL) and antidotal treatment (obidoxime plus atropine) on tabun-induced neurotoxicity, male albino rats were poisoned with a lethal dose of tabun (280 mg/kg i.m.; 100% of LD50 value) and observedat 24 hours and 7 days following tabun challenge. The neurotoxicity of tabun was evaluated using a Functional observational battery and an automatic measurement of motor activity. Pharmacological pretreatment as well as antidotal treatment were a ble toeliminate most of tabun-induced neurotoxic effects observed at 24 hours following tabun poisoning. However, there was not significant difference between the efficacy of PANPAL and antidotal treatment to eliminate tabun-induced neurotoxicity in rats. Thecombination of PANPAL pretreatment and antidotal treatment seems to be slightly more effective in the elimination of tabun-induced neurotoxicity in rats at 24 hours following tabun challenge in comparison with the administration of PANPAL

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

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Volume of the periodical

185

Issue of the periodical within the volume

1-2

Country of publishing house

IE - IRELAND

Number of pages

11

Pages from-to

129-139

UT code for WoS article

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EID of the result in the Scopus database

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