Prevalence of hepatitis C virus in adult population in the Czech Republic - time for birth cohort screening

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG33__%2F17%3AN0000011" target="_blank" >RIV/60162694:G33__/17:N0000011 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/17:43875748 RIV/00216208:11150/17:10366092 RIV/00179906:_____/17:10366092

Result on the web

<a href="http://dx.doi.org/https://doi.org/10.1371/journal.pone.0175525" target="_blank" >http://dx.doi.org/https://doi.org/10.1371/journal.pone.0175525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/https://doi.org/10.1371/journal.pone.0175525" target="_blank" >https://doi.org/10.1371/journal.pone.0175525</a>

Result language

angličtina

Original language name

Prevalence of hepatitis C virus in adult population in the Czech Republic - time for birth cohort screening

Original language description

Chronic hepatitis C is curable disease. Low detection rate could be one of the reasons of poor treatment uptake. It is important to identify HCV prevalence and anti-hepatitis C virus (HCV) positive patients in population by effective screening strategy such as risk-based or birth cohort screening programs. There are no national population-based estimates of the HCV prevalence in the Czech Republic (CZ). The most recent seroprevalence survey determined a prevalence of positive anti-HCV antibodies of 0.2% (in 2001). The aim of the study was to determine the seroprevalence of HCV, HCV viraemia and HCV genotype in the CZ adult population. We also estimated the number of persons living with chronic hepatitis C in CZ. The examined group included 3000 adults, 18-90 years of age enrolled in 2015. All serum samples were examined to determined anti-HCV antibodies positivity, HCV-RNA positivity and genotypes. Of the 3000 samples, 50 were found to be anti-HCV-positive, for a seroprevalence of 1.67% (2.39% in males, 0.98% in females). The overall prevalence of positive HCV RNA was 0.93%: 1.5% in males, 0.39% in females. HCV genotype (GT) 1a was determined in 25%, GT 1b in 25% and GT 3a in 46%. Since 2001, the HCV seroprevalence has increased 8-fold. The highest HCV seroprevalence occurred in males aged 30-44 years. We can estimate that there are more than 140,000 people with HCV antibodies and more than 80,000 people with chronic hepatitis C living in the CZ. The introduction of birth cohort HCV screening could be beneficial for the country.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30302 - Epidemiology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

1932-6203

Volume of the periodical

neuveden

Issue of the periodical within the volume

April

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

nestrankovano

UT code for WoS article

000399955400065

EID of the result in the Scopus database

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