Anthrax toxin: deadly triumvirate of anthrax

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F03%3A00001003" target="_blank" >RIV/60162694:G38__/03:00001003 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/03:00003916
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Anthrax toxin: deadly triumvirate of anthrax
Original language description
Anthrax not a common disease for humans is caused by large bacterium, Bacillus anthracis, producing a deadly anthrax toxin. The toxin comprises three proteins, called protective antigen (PA), lethal factor (LF) and edema factor (EF). These three toxic proteins are critical for the deadly effect of the anthrax bacterium, B. anthracis. One of these toxins (PA) allows the other anthrax toxin components to enter cells. The second protein (LF) destroys immune system cells that normally defend the body. Thisprocess releases inflammatory molecules that can cause sepsis-related shock and death. The third protein (EF) causes potentially lethal swelling and fluid buildup in the body. By itself, edema factor can be deadly. It also makes lethal factor 10 to 100 times more potent. All these proteins create deadly triumvirate, miniature molecular machine which pierce into cells and kill them.
Czech name
Antroxový toxin: smrtící triumvirát antraxu
Czech description
Antroxový toxin: smrtící triumvirát antraxu

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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