In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001071" target="_blank" >RIV/60162694:G38__/04:00001071 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
Original language description
Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide), K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butan dibromide) were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with thecurrently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, andcomparable with the potency of the obidoxime at human relevant doses.
Czech name
In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048
Czech description
In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Central European Journal of Public Health
ISSN
1210-7778
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
Suppl.
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
"S59"-"S61"
UT code for WoS article
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EID of the result in the Scopus database
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