The evaluation of tabun-induced cognitive impairment in rats and its antidotal treatment using the water maze test

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001179" target="_blank" >RIV/60162694:G38__/04:00001179 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The evaluation of tabun-induced cognitive impairment in rats and its antidotal treatment using the water maze test
Original language description
The mechanism of nerve agents (Tabun, Soman, Sarin, VX, etc.) toxicity consists in the irreversible inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) resulting in excessive acetylcholine effects within the nervous system. The peripheral cholinergic system is well understood, while the central nervous system picture continues to evolve. Central cholinergic system is important for protective systems, locomotion, alertness and memory and in the regulation of a number of cyclic and periodic behaviors. Nerve agent-induced cholinergic effects are usually manifested immediately following high-level exposure, nevertheless, behavioural alterations and impairments of cognitive functions were found following acute exposure to nerve agents in the absence of any classic signs of cholinergic toxicity. Recently, researches are interested in such antidotes that not only allow live nerve agents-poisoned men, but also improve their life by the improvement of their central cognitive functions.
Czech name
Hodnocení kognitivního poškození tabunem u potkanů a jeho antidotní léčba
Czech description
Hodnocení kognitivního poškození tabunem u potkanů a jeho antidotní léčba

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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