Organ weight changes in mice after long-term inhalation exposure to manganese oxides nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG42__%2F15%3A00533780" target="_blank" >RIV/60162694:G42__/15:00533780 - isvavai.cz</a>

Result on the web

<a href="http://vavtest.unob.cz/registr" target="_blank" >http://vavtest.unob.cz/registr</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1742-6596/617/1/012018" target="_blank" >10.1088/1742-6596/617/1/012018</a>

Result language

angličtina

Original language name

Organ weight changes in mice after long-term inhalation exposure to manganese oxides nanoparticles

Original language description

Recently, it has been proven that manganese from inhaled particles of manganese compounds can accumulate in the internal organs of laboratory animals. Nevertheless, there were only a few researches dealing with changes in body morphology induced by inhalation of these particles, even though results of some studies indicate existence of such changes. The aim of our research was to assess the effect of inhaled manganese oxides nanoparticles on weight of internal organs. For this purpose a long-term inhalation experiment on laboratory mice was performed, during which the mice were exposed to MnO.Mn2O3 nanoparticles in concentration 2 x 106 particles/cm3 for 17 weeks, 24 hours a day, 7 days a week. Manganese oxides nanoparticles were synthesized continuously via aerosol route in a hot wall tube flow reactor using thermal decomposition of metal organic precursor manganese(II)acetylacetonate in the flow tube reactor at temperature 750 °C in the presence of 30 vol% of oxygen. It was proven that inhaled nanoparticles can influence the weight of internal organs of mice. Moreover, it was discovered that the resulting change in weight of selected organs is disproportional. The mice from the experimental group had statistically significantly lighter kidneys, liver and spleen and heavier pancreas compared to the mice from the control group.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Journal of Physics: Conference Series

ISBN

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ISSN

1742-6588

e-ISSN

—

Number of pages

6

Pages from-to

1-6

Publisher name

IOP PUBLISHING LTD

Place of publication

BRISTOL

Event location

Grenoble, FRANCE

Event date

Nov 18, 2014

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000358033300018