Effective bisquaternary reactivators of tabun-inhibited AChE

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001313" target="_blank" >RIV/60162694:G44__/05:00001313 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/05:00007142
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effective bisquaternary reactivators of tabun-inhibited AChE
Original language description
Two cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun-inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime, and HI-6) were practically without reactivation potency. On the other hand, oximes K074, K075 and trimedoxime were satisfactorily effective. Moreover, K-oximes reactivated tabun-inhibited AChE at lower concentration (10-4 and 10-3 M) in comparisonwith trimedoxime (10-3 and 10-2 M). Thus, K-oximes can be considered as the most effective reactivators of tabun-inhibited AChE at present.
Czech name
Účinné biskvarterní reaktivátory tabunem inhibované AChE
Czech description
Účinné biskvarterní reaktivátory tabunem inhibované AChE.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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