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Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001447" target="_blank" >RIV/60162694:G44__/06:00001447 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/06:00006893

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

  • Original language description

    Six AChE reactivators with propane linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxon was tested in vitro. The reactivation efficaciesof pralidoxime, HI-6, obidoxime and six synthesized reactivators were compared. According to the results obtained, three reactivators seem to be promising against paraoxon-inhibited AChE. Better results were obtained for bisquaternary substances at least with one oxime group in position four. None of the tested substances was able to satisfactorily reactivate tabun-inhibited AChE.

  • Czech name

    Syntéza bispyridiniových sloučenin nesoucích propanový spojovací řetězec a hodnocení jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesteráze

  • Czech description

    Byly syntetizovány nové reaktivátory acetylcholinesterázy mající propánový spojovací řetězec mezi dvěmi pyridiniovými jádry. Následně byla testována jejich schopnost reaktivovat acetlycholinesterázu inhibovanou paraoxonem a tabunem.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Letters in Organic Chemistry

  • ISSN

    1570-1786

  • e-ISSN

  • Volume of the periodical

    3

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    5

  • Pages from-to

    831-835

  • UT code for WoS article

  • EID of the result in the Scopus database