Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001447" target="_blank" >RIV/60162694:G44__/06:00001447 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/06:00006893

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

Original language description

Six AChE reactivators with propane linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxon was tested in vitro. The reactivation efficaciesof pralidoxime, HI-6, obidoxime and six synthesized reactivators were compared. According to the results obtained, three reactivators seem to be promising against paraoxon-inhibited AChE. Better results were obtained for bisquaternary substances at least with one oxime group in position four. None of the tested substances was able to satisfactorily reactivate tabun-inhibited AChE.

Czech name

Syntéza bispyridiniových sloučenin nesoucích propanový spojovací řetězec a hodnocení jejich reaktivační aktivity proti tabunem a paraoxonem inhibované acetylcholinesteráze

Czech description

Byly syntetizovány nové reaktivátory acetylcholinesterázy mající propánový spojovací řetězec mezi dvěmi pyridiniovými jádry. Následně byla testována jejich schopnost reaktivovat acetlycholinesterázu inhibovanou paraoxonem a tabunem.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Letters in Organic Chemistry

ISSN

1570-1786

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

11

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

5

Pages from-to

831-835

UT code for WoS article

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EID of the result in the Scopus database

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