New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001450" target="_blank" >RIV/60162694:G44__/06:00001450 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/06:00006897

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE

Original language description

Nine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be the most potent AChE reactivator. The reactivation potency of these compounds depends on structural factors such as presence of quaternary nitrogens, length of the linking chain between both pyridinium rings, and position of the oxime moiety at the pyridinium ring.

Czech name

Nové metody v syntéze reaktivátorů acetylcholinesterasy a testování jejich schopnosti reaktivovat cyklosarinem inhibovanou acetylcholinesterasy

Czech description

Bylo připraveno devět potenciálních reaktivátorů AChE a testováno na cyklosarinem inhibovaném enzymu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Papers-Chemicke Zvesti

ISSN

0366-6352

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

48-51

UT code for WoS article

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EID of the result in the Scopus database

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