Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibitied by paraoxon

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001457" target="_blank" >RIV/60162694:G44__/06:00001457 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibitied by paraoxon

Original language description

Oximes are cholinesterase reactivators of use in poisoning with (PRX) is used clinically as an adjunct to atropine in such exposure. Clinical experience with PRX (organophosphorus compounds. Pralidoxime and other oximes) is,however, disappointing and routine use has been questioned. In addition it is known that oximes are not equally effective against all existing organophosphorus compounds. There is a clear demand for #broad spectrum# cholinesterase reactivators with a higher efficacy than PRX.Over theyears new reactivators of cholinesterase of potential clinical utility have been developed. Their chemical structures were derived from those of existing esterase reactivators, especially pralidoxime, obidoxime and HI-6. The purpose of the study was toquantify in vitro the extent of oxime (pralidoxime, K-27, K-33, K-48, methoxime and BI-6) conferred protection, using paraoxon as an inhibitor. Paraoxon (POX), the active metabolite of parathion (O,Odiethyl- O-p-nitro-phenyl phosphorothio

Czech name

Pět oximů (K-27, K-33, K-48, BI-6 a methoxim) ve srovnání s pralidoximem: in vitro reaktivace acetylcholinestrerázy červených krvinek inhibovaných paraoxonem

Czech description

Byly testovány nové reaktivátory AChE # K033, K027 a K048 pro svou schopnost reaktivovat erythrocytální AChE inhibovanou pesticidem paraoxonem pomocí metody in vitro.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

64-71

UT code for WoS article

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EID of the result in the Scopus database

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