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Hepatitis A/B vaccination of adults over 40 years old: Comparison of three vaccine regiments and effect of influencing factors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001467" target="_blank" >RIV/60162694:G44__/06:00001467 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Hepatitis A/B vaccination of adults over 40 years old: Comparison of three vaccine regiments and effect of influencing factors

  • Original language description

    Challenged by contrasting data on low immune responses in the elderly with a combined hepatitis A/B vaccine, a randomised, controlled study was conducted to assess the immunogenicity of three hepatitis A and B vaccination regimens (group 1: combined hepatitis A/B vaccine Twinrix# [GSK]; group 2: co-administered hepatitis A vaccine, Havrix# [GSK] + hepatitis B vaccine Engerix#-B [GSK], group 3: co-administered hepatitis A vaccine, Vaqta# [Sanofi-Pasteur MSD] + hepatitis B vaccine HB VAX PRO# [Sanofi-Pasteur MSD]) and the effect of influencing factors in subjects >40 years. On completion of the full vaccination course, anti-HBs seroprotection (SP) rates were 92, 80 and 71% in groups 1, 2 and 3, respectively; anti-HAV seropositivity (S+) rates were 97, 99and 99%, respectively. In group 1, anti-HBs SP rate was non-inferior as well as superior and anti-HAV S+ rate was non-inferior to that in groups 2 and 3. Anti-HBs response was most significantly influenced by the vaccine regimen, followe

  • Czech name

    Očkování proti virovým hepatitidám A a B u osob starších 40 let: Srovnání tří vakcín a posouzení působení ovlivňujících faktorů

  • Czech description

    Očkování proti virovým hepatitidám A a B u osob starších 40 let: Srovnání tří vakcín a posouzení působení ovlivňujících faktorů.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FN - Epidemiology, infection diseases and clinical immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vaccine

  • ISSN

    0264-410X

  • e-ISSN

  • Volume of the periodical

    24

  • Issue of the periodical within the volume

    26

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    5509-5515

  • UT code for WoS article

  • EID of the result in the Scopus database