Photometric microplate assay for estimation of paraoxon inhibited acetylcholinesterase reactivation efficacy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F08%3A00001991" target="_blank" >RIV/60162694:G44__/08:00001991 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Photometric microplate assay for estimation of paraoxon inhibited acetylcholinesterase reactivation efficacy
Original language description
Photometric microplate assay was performed for testing of paraoxon-inhibited acetylcholinesterase (AChE). Three reactivators were used for reactivation purposes: obidoxime, pralidoxime, and HI-6. 3-D graphs (percent of reactivation vs. concentration of reactivator and vs. time of reactivator effecting) were constructed for each reactivator to compare their efficacy. The best results were obtained when obidoxime was applied; reactivation was near to 80 %. Suitability of photometric microplates for following of reactivation procedures was mentioned in this work.
Czech name
Fotometrické multikanálové stanovení účinnosti reaktivace acetylcholinesterázy inhibované paraoxonem
Czech description
Multikanálová spektrofotometrie na titrační destičce byla použita pro testování reaktivace paraoxonem inhibované acetylcholinesterázy (AChE). Tři reaktivátory byly použity: obidoxim, pralidoxim a HI-6. 3-D grafy (procento reaktivace vs. koncentrace reaktivátoru vs. čas působení) byly konstruovány pro každý reaktivátor tak aby byla porovnána jejich účinnost. Nejlepší výsledky byly dosaženy s obidoximem (reaktivace 80%). Použitelnost prezentované metody je diskutována v práci.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN
1475-6366
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
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UT code for WoS article
000260847500005
EID of the result in the Scopus database
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