Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002132" target="_blank" >RIV/60162694:G44__/09:00002132 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?

Original language description

Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 ?g/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and allanimals died.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-0287

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

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UT code for WoS article

000267953800003

EID of the result in the Scopus database

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