Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002202" target="_blank" >RIV/60162694:G44__/09:00002202 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13440/09:00004895
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited
Original language description
Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial. In this study, we wanted to summarize if obidoxime is a universal reactivator orif its reactivation potency in case of some organophosphorus inhibitors is limited. Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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