Development of promising oximes against nerve agent and/or pesticide intoxication

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002301" target="_blank" >RIV/60162694:G44__/10:00002301 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/10:00300617

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Development of promising oximes against nerve agent and/or pesticide intoxication

Original language description

Acetylcholinesterase (AChE) reactivators are crucial antidotes for the treatment of organophosphate (OP) intoxication. Since pralidoxime, there is still no AChE reactivator able to counteract the full spectrum of different organophosphorus compounds. Oureffort has been concerned on development of novel AChE reactivators against tabun and OP pesticides. Hundreds of novel AChE reactivators were prepared. Several novel compounds were found to be potent reactivators both in vitro and in vivo. One compound(K203) was highlighted against tabun poisoning and one compound (K027) was highlighted against OP pesticide poisoning. Selected compounds are becoming promising candidates for replacement of former clinically used AChE reactivators.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/OVUOFVZ200801" target="_blank" >OVUOFVZ200801: Robotized system for in vitro evaluation of novel rectivators of acetylcholinesterase inhibited by nerve agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Main Group Chemistry

ISSN

1024-1221

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

3-4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

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UT code for WoS article

000287057100012

EID of the result in the Scopus database

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