Interaction of nerve agent antidotes with cholinergic systems

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002377" target="_blank" >RIV/60162694:G44__/10:00002377 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/10:00300578 RIV/68407700:21340/10:00166812

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interaction of nerve agent antidotes with cholinergic systems

Original language description

The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been developed yet and other therapeutic approaches not related to reactivation of acetylcholinesterase are being investigated. This review describes the main features of the cholinergic system, cholinergic receptors, cholinesterases and their inhibitors. It also focuses on the organophosphorus nerve agents, their properties, effects and a large partdescribes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed. These antidotal effects principally includeoxime interactions with muscarinic and nicotinic receptors.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Medicinal Chemistry

ISSN

0929-8673

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

16

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

11

Pages from-to

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UT code for WoS article

000277120200005

EID of the result in the Scopus database

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