Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002435" target="_blank" >RIV/60162694:G44__/11:00002435 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/11:00367444

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/60/60_679.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/60/60_679.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors

Original language description

Current treatment of organophosphorus poisoning, resulting in overstimulation and desensitization of muscarinic and nicotinic receptors by acetylcholine (ACh), consists of the administration of atropine and oxime reactivators. In our study, we focused onthe interesting non-acetylcholin-esterase property of oximes. Two standard reactivators (HI-6, obidoxime) and two new compounds (K027 and K203) were chosen for in vitro (patch clamp) and in vivo (nerve-evoked muscle contraction) testings. Both examinations showed antinicotinic effects of the reactivators. In vitro inhibition of acetylcholine-evoked currents by obidoxime, HI-6 and K203 was equivalent while K027 was less potent. Similar order of potency was observed by the in vivo examinations. We thus confirm previous in vitro results, which describe antinicotinic effects of oxime reactivators, and furthermore, we show in vivo antagonism of oxime reactivators exerted by the inhibition of ACh effect on the nicotinic receptor in the junct

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

679-686

UT code for WoS article

000295057100010

EID of the result in the Scopus database

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