Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002447" target="_blank" >RIV/60162694:G44__/11:00002447 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/138527211794072579" target="_blank" >http://dx.doi.org/10.2174/138527211794072579</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents
Original language description
A number of oxime reactivators have been synthesized and studied for the antidotal treatment of poisoning by toxic organophosphorus agents, and several oximes are currently available to reactivate the organophosphorus agents-induced acetylcholinesteraseinhibition. However, there is no oxime with broad spectrum suitable for the antidotal treatment of poisoning with various organoposphorus warfare agents as well as insecticides. In addition, current available oximes have very limited brain-blood barrier(BBB) penetration, even though hydrophobic toxic organophosphorus agents can easily penetrate BBB.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/ME09086" target="_blank" >ME09086: Development of novel antidotal treatment against organophosphorus pesticides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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