Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874626" target="_blank" >RIV/60162694:G44__/12:43874626 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/12:43908626

Result on the web

<a href="http://dx.doi.org/10.2478/s11532-012-0064-8" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0064-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11532-012-0064-8" target="_blank" >10.2478/s11532-012-0064-8</a>

Result language

angličtina

Original language name

Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats

Original language description

Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Chemistry

ISSN

1895-1066

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

5

Country of publishing house

PL - POLAND

Number of pages

10

Pages from-to

1442-1451

UT code for WoS article

000306695700005

EID of the result in the Scopus database

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