Characterization of CD34(+) thymocytes in newborn dogs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874712" target="_blank" >RIV/60162694:G44__/12:43874712 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/12:#0000915
Result on the web
<a href="http://dx.doi.org/10.1016/j.vetimm.2012.04.006" target="_blank" >http://dx.doi.org/10.1016/j.vetimm.2012.04.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vetimm.2012.04.006" target="_blank" >10.1016/j.vetimm.2012.04.006</a>

Result language
angličtina
Original language name
Characterization of CD34(+) thymocytes in newborn dogs
Original language description
Using two-color flow cytometry, we characterized CD34(+) cells in the newborn canine thymus. CD34(+) thymic cells comprised approximately 5% of cells recovered by thymus tissue teasing and both large and small thymocytes have been present in this population, the former being 7-12 times more frequent. All CD34(+) cells expressed the pan-leukocyte antigen CD45. The expression of CD44 profile on the large and small CD34(+) thymocytes differed: almost all large CD34(+) cells were CD44(+), while only 75% ofsmall CD34(+) thymocytes co-expressed the CD44 antigen. We have previously described that CD172 alpha is present on the surface of CD34(+) bone marrow cells in dogs. In the thymus, CD172 alpha was expressed on 5-10% and less than 5% of large and small CD34(+) cells, respectively. Some CD34(+) thymocytes also co-expressed T-lineage-specific markers like CD3, CD4, CD8,TCR1 and TCR2. Their expression increased during the large-to-small thymocyte transition. Based on our findings we suggest
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/ED0006%2F01%2F01" target="_blank" >ED0006/01/01: Center for Advanced Microbiology & Immunology Research in Veterinary Medicine</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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