Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with the oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874871" target="_blank" >RIV/60162694:G44__/13:43874871 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12083/abstract;jsessionid=0C1E9A26B087EB89A3C5DB920EBC28BA.f04t02" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12083/abstract;jsessionid=0C1E9A26B087EB89A3C5DB920EBC28BA.f04t02</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.12083" target="_blank" >10.1111/bcpt.12083</a>

Result language
angličtina
Original language name
Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with the oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats
Original language description
The ability of newly developed oximes to decrease tabun-induced acute neurotoxicity was slightly higher than that of trimedoxime and the oxime K203 but the difference of neuroprotective efficacy among all oximes studied is not so high to make the decision about the replacement of commonly used oximes (especially trimedoxime and obidoxime) in the treatment of acute tabun poisonings.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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