Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875220" target="_blank" >RIV/60162694:G44__/14:43875220 - isvavai.cz</a>
Result on the web
<a href="http://www.degruyter.com/view/j/intox.2013.6.issue-4/intox-2013-0029/intox-2013-0029.xml" target="_blank" >http://www.degruyter.com/view/j/intox.2013.6.issue-4/intox-2013-0029/intox-2013-0029.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/intox-2013-0029" target="_blank" >10.2478/intox-2013-0029</a>

Result language
angličtina
Original language name
Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)
Original language description
Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment process based on administration of antidote. Here, Wistar rats were exposed to SM doses 0 - 40 mg/kg and they were treated with a compound HI-6. Thetreatment provided no significant effect on ferric reducing antioxidant power of blood and plasma. However, HI-6 caused increase of thiobarbituric acid reactive substances level. This stresogenic response was probable reason that both blood level of glutathione reductase activity and reduced glutathione were significantly elevated. We infer suitability of HI-6 prophylactically enhance oxidative stress protection by small oxidative insult.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)