A comparison of cholinesterase inhibitors in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T-maze

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875241" target="_blank" >RIV/60162694:G44__/14:43875241 - isvavai.cz</a>
Result on the web
<a href="http://www.journals.elsevier.com/journal-of-applied-biomedicine/recent-articles/" target="_blank" >http://www.journals.elsevier.com/journal-of-applied-biomedicine/recent-articles/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2014.01.006" target="_blank" >10.1016/j.jab.2014.01.006</a>

Result language
angličtina
Original language name
A comparison of cholinesterase inhibitors in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T-maze
Original language description
Cholinesterase inhibitors are beneficial in the treatment of Alzheimer's disease via indirect increase of cholinergic neuro-transmission. The aim of the present study was to evaluate the potency of inhibitors tacrine, rivastigmine and donepezil to reverse cholinergic depletion induced by 3-quinuclidinyl benzilate (QNB, 2 mg kg(-1)) in Wistar rats performing the multiple T-maze test. The effect of QNB on retention was compared to the effect of standard amnesic drug, scopolamine, at the dose of 0.3 mg kg(-1). Well-trained rats were treated intra-peritoneally with QNB, followed by another injection containing saline or tacrine (10 mg kg(-1)) or rivastigmine (1.2 mg kg(-1)) or donepezil (2.65 mg kg(-1)) 15 min later. Rats were subjected to the T-maze task30 min and 24 h following QNB administration. The passage time and number of errors were observed. QNB significantly impaired the performance of rats in both tested times in contrast to short-lasting effect of scopolamine (30 min only). T
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F12%2F0611" target="_blank" >GAP303/12/0611: Neurobehavioral evaluation of potential Alzhemier`s disease drugs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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