Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875538" target="_blank" >RIV/60162694:G44__/14:43875538 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1382668914000027" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1382668914000027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etap.2014.01.001" target="_blank" >10.1016/j.etap.2014.01.001</a>

Result language

angličtina

Original language name

Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro

Original language description

Acetylcholinesterase (AChE) is an important part of cholinergic nerves where it participates in termination of neurotransmission. AChE can be inhibited by e.g. some Alzheimer disease drugs, nerve agents, and secondary metabolites. In this work, metal salts aluminium chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. Standard Ellman assay based on human recombinant AChE was done and inhibition was measured using Dixon plot. No inhibition was proved for sodium, potassium and magnesium ions. However, aluminium, cupric, ferric and calcium ions were able to inhibit AChE via noncompetitive mechanism of inhibition. Though the inhibition is muchweaker when compared to e.g. drugs with noncompetitive mechanism of action, biological relevance of the findings can be anticipated.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

455-459

UT code for WoS article

000332919800051

EID of the result in the Scopus database

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