Novel caffeine derivatives with antiproliferative activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F16%3A43875580" target="_blank" >RIV/60162694:G44__/16:43875580 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/16:10323426 RIV/00179906:_____/16:10323426

Result on the web

<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA22889A#!divAbstract" target="_blank" >http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA22889A#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c5ra22889a" target="_blank" >10.1039/c5ra22889a</a>

Result language

angličtina

Original language name

Novel caffeine derivatives with antiproliferative activity

Original language description

Caffeine is probably the best known and most widely used psychoactive substance in the world. Beside its psychoactive effects, caffeine has been found to affect the cell cycle and DNA repair, as a consequence of the inhibition of ATM and ATR kinases. These two DNA damage response kinases, members of the phosphatidylinositol 3-kinase related protein kinase family, represent very attractive anticancer drug targets. Their inhibition can selectively sensitize cancer cells to DNA damaging agents and even kill various tumour cells in monotherapy. We developed a series of caffeine derivatives and evaluated their antiproliferative effects on 11 human tumour cell lines and compared them against caffeine and a standard ATR inhibitor VE-821. Although the new caffeine derivatives did not achieve the overall potency of VE-821, several compounds exhibited enhanced antiproliferative activity compared to caffeine and in some cell lines showed at least comparable activity to VE-821.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RSC Advances

ISSN

2046-2069

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

39

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

32534-32539

UT code for WoS article

000374045900016

EID of the result in the Scopus database

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