Freund's complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F16%3A43875603" target="_blank" >RIV/60162694:G44__/16:43875603 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43410/16:43909723 RIV/00216275:25520/16:39901163
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=4761&session_id=0428e0508447272d4dc92fe013295bb7" target="_blank" >http://www.elis.sk/download_file.php?product_id=4761&session_id=0428e0508447272d4dc92fe013295bb7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2016_052" target="_blank" >10.4149/BLL_2016_052</a>

Result language
angličtina
Original language name
Freund's complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge
Original language description
Freund's complete adjuvant (FCA) is a mean used for improving immunization efficacy in experiments and veterinary medicine. Despite high efficacy, it is not used in human vaccination due to number of adverse effects. Arthritis can be an example of a typical adverse consequence. In this work, we decided to investigate the link between oxidative stress and inflammation in animals exposed to FCA. BALB/c mice received either saline or FCA in doses 10-50 mu l and were euthanized from one to three days after infection. Interleukins (IL) IL-2, IL-4 and tumor necrosis factor a (TNF-alpha) were determined in plasma. Ferric reducing antioxidant power (FRAP), malondialdehyde by thiobarbituric acid reactive substances assay (TBARS), reduced glutathione (GSH) and caspase-3 were measured in livers, muscles and other organs. We determined significant effect of FCA on TBARS and GSH in the livers. Beside this, TBARS were altered in muscles as well. Inflammation was confirmed by increased level of TNF-a. Taking the results into account, we infer that the harmful effect of FCA is mediated not only by inflammation but also by oxidative. This should be considered when pathological consequences of FCA are scored (Fig. 4, Ref. 21). Text in PDF www.elis.sk.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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